Opioids are used to treat cases of acute and chronic pain that arise from a variety of causes, ranging from trauma to palliative care for advanced illness. Every year, 100 million people in the United States suffer from pain, 9-12 million of whom have chronic or persistent pain. Although opioid therapy is an important component of pain management for many patients, the addictive and euphoric properties of these drugs make them liable to misuse, abuse, addiction, and diversion.
In an effort to help tackle the public health crisis of opioid dependence, misuse, and addiction that has emerged over the last decade, drug manufacturers have begun to develop abuse-deterrent formulations of opioid medications (ADFs). ICER will review available evidence on the comparative clinical effectiveness and comparative value of ADFs in order to inform decision-making by patients, clinicians and policy-makers, within the context of multiple efforts being undertaken to combat the opioid crisis. ICER’s review will also analyze the potential of ADFs to reduce the burden of prescription opioid abuse by evaluating their benefits and market penetration based on coverage policies and legislation.
Interventions of Interest:
- Hysingla® ER (Hydrocodone, Purdue)
- Vantrela® (Hydrocodone , Teva)
- Arymo® ER ( Morphine, Egalet)
- Embeda® (Morphine + naltrexone, Pfizer)
- MorphabondTM (Morphine extended release, Inspirion Delivery Technologies)
- OxyContin® TR (Oxycodone, Purdue)
- Xtampza®ER (Oxycodone, Collegium Pharmaceutical Inc)
- Targiniq® (Oxycodone + naloxone extended release, Purdue)
- Troxyca® ER (Oxycodone + naltrexone, Pfizer)
- RoxyBond® (Oxycodone, Inspirion Delivery Technologies)
Date of Review: July 2017
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ICER will develop a report reviewing the clinical effectiveness and value of abuse-deterrent opioids. The report will be the subject of a July 20, 2017 meeting of the New England CEPAC.
ICER’s Draft Scoping Document for a review of abuse-deterrent opioid formulations. This scoping document was open to public comment for three weeks.
Public Comment on Draft Scoping Document.