CAR-T Therapies


ICER will develop a report on chimeric antigen receptor t-cell (CAR-T) therapies for treatment of B-cell malignancies. ICER’s report will consider the comparative clinical effectiveness and value of tisagenlecleucel (KymriahTM , Novartis) and axicabtagene ciloleucel (YescartaTM, Kite Pharma). Both agents were approved in 2017. Tisagenlecleucel is approved for treatment of relapsed or refractory B-cell acute lymphoblastic leukemia in pediatric and young adult patients. Novartis is also expected to file later this year for a second indication for diffuse large B-cell lymphoma in adults. Axicabtagene ciloleucel is approved for the treatment of relapsed or refractory aggressive non-Hodgkin’s lymphoma in adult patients.

Date of Review: March 2018


For questions or additional information, please contact

Associated Meetings

March 2, 2018 10am-4pm PT

Preservation Park (Nile Hall)
1233 Preservation Park Way
Oakland CA, 94612

The California Technology Assessment Forum will convene to discuss evidence on CAR-T therapies.

Key Dates

Associated Materials