Psoriasis

New England CEPAC

Plaque psoriasis is a common disease that causes red, scaly, raised lesions on the skin, most commonly on the elbows, knees, scalp, and back. Psoriasis affects about 2% of the population and significantly decreases health-related quality of life, particularly if lesions are in areas that can affect daily functioning (e.g., the hands or soles of the feet) or affect social functioning (e.g., the face). Psoriasis is a chronic inflammatory condition that is associated with systemic diseases including psoriatic arthritis, other autoimmune diseases, the metabolic syndrome, and cardiovascular disease.

Interventions of interest:

Anti TNF agents:

  • Adalimumab (Humira®, AbbVie)
  • Etanercept (Enbrel®, Amgen, Inc.)
  • Infliximab (Remicade®, Janssen)

Anti IL-17A agents:

  • Secukinumab (Cosentyx®, Novartis)
  • Ixekizumab (Taltz®, Eli Lilly and Co.)
  • Brodalumab (SiliqTM, Valeant Pharmaceuticals and AstraZeneca)

Anti IL-12/23 agent:

  • Ustekinumab (Stelara®, Janssen)

Anti PDE4 agent:

  • Apremilast (Otezla®, Celgene)

Included in planned 2018 Condition Update:

Anti IL-23 agents:

  • Guselkumab (Tremfya®, Janssen/Johnson & Johnson)
  • Tildrakizumab (Sun Pharma)

TNF inhibitor

  • Certolizumab pegol (Cimzia®, UCB)

ASSOCIATED MEETING & MATERIALS

New England CEPAC
July 12, 2018 10am - 4pm ET

TBD

The New England CEPAC will convene to review ICER's condition update on therapies for plaque psoriasis. During this meeting, the Council will also review a report on elagolix for endometriosis.

Key Dates

Associated Materials

11/09/2017 – 11/30/2017

12/04/2017

12/04/2017

12/04/2017 – 12/22/2017

01/09/2018

04/27/2018
Draft Evidence Report

04/27/2018
Draft Voting Questions

04/27/2018 – 05/25/2018
Public Comments

06/08/2018
Response to Comments

06/08/2018
Evidence Report

06/08/2018
Revised Voting Questions

07/12/2018
Meeting Agenda

07/27/2018
Final Evidence Report and Meeting Summary


ASSOCIATED MEETING & MATERIALS

New England CEPAC
November 18, 2016 10AM-4PM

The Joseph B. Martin Conference Center at Harvard Medical School
77 Avenue Louis Pasteur, Boston, MA 02115

The New England CEPAC convened to deliberate and vote on evidence presented in ICER's report on treatments for psoriasis.

Key Dates

Associated Materials

06/24/2016

07/15/2016

07/25/2016

09/29/2016

This report was open to public comment until October 20, 2016.


09/29/2016

09/29/2016

11/04/2016

The public comment period on the Draft Evidence Report has closed.


11/04/2016

11/04/2016

11/04/2016

11/18/2016

Public meeting of the New England CEPAC in Boston, MA